Advances in clinical and translational research necessitate that data generated by academic institutions and commercial entities are accessible to bench scientists, translational researchers, and clinicians. In addition, scientists need to have access to high quality, well annotated biospecimens to validate their research and correlate their findings with the associated pathology and clinical annotations. caTissue is caBIG^TM's biospecimen informatics system for inventory tracking and clinical and pathology annotation. caTissue permits users to track the collection, storage, quality assurance, and distribution of specimens as well as the derivation and aliquotting of new specimens from existing ones (e.g. for DNA analysis). Furthermore, it allows users to find and request specimens that may then be used in molecular, correlative studies.